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Our Study

If you’re like many women or men in the early stages of treating hormone receptor positive (HR+) breast cancer, you are likely using or will use endocrine therapy.

Adjuvant therapy is therapy given after your surgery (neoadjuvant therapy is given prior to your surgery). Adjuvant endocrine therapy is the standard of care provided to patients with early stage HR+ breast cancer following surgery, chemotherapy, and/or radiation in order to lower the chance of cancer returning.

We are seeking both women and men who have recently undergone or are scheduled to undergo surgery, chemotherapy or radiation to treat HR+, HER2- early stage breast cancer.

The monarchE study is evaluating an investigational medication to learn if it may lower the chances of cancer returning even more, when paired with endocrine therapy.


In order to be considered for this research study, candidates must:

Have confirmed Hormone Receptor positive (HR+) /HER2 negative (HER2-) early stage breast cancer

Have undergone surgery and/or their last chemotherapy and/or radiation treatment.

Both women and men are eligible for our study.

There are other eligibility requirements. A final determination on whether this research study might be suitable will be made after a consultation with a study doctor or study coordinator/nurse from one of the participating research sites.

Find a Study Center

Breast Cancer specialists throughout the country are seeking study participants. Enter your zip code below to find a study center near you.

About Clinical Research

A clinical trial is a scientific study in people that helps to determine if and how a drug or therapy works. These can also be called clinical studies, or clinical research. Clinical research helps us answer specific questions about an investigational drug, such as:


Is it effective?

Is it more effective than another established treatment?

Is it safe and/or what are its side effects?


The development of a new medicine can take more than 10 years. Although long, this length of time is vital to ensure each medicine is tested rigorously.

If you’re considering participating in a clinical trial or participation for a friend or loved one, visit our parent website, Lilly TrialGuide to learn more.

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